KaryoSolver
Bridging Academic Innovation and Industrial Applications: Our Partnership with 4bases
Redefining Cytogenomics: Speed, Resolution, and Interactivity
The core innovation of KaryoSolver lies in its ability to completely redefine the timeline and efficiency of molecular karyotyping. Traditional techniques, such as array-CGH (Comparative Genomic Hybridization), typically require 2 to 3 days of complex laboratory hybridization and processing. In contrast, KaryoSolver delivers high-resolution, genome-wide copy number profiles within hours, making large chromosomal abnormalities visible after just 1 to 2 hours of real-time Nanopore sequencing.
Crucially, the software features flexible and progressive resolution: as the sequencing run continues, the detail and sensitivity increase dynamically, matching the performance of standard platforms but in a fraction of the time. Furthermore, KaryoSolver introduces an intuitive, interactive dashboard for data exploration. Users can visualize genetic alterations across the entire genome through clear, clickable plots, and easily filter the results. By adjusting user-friendly thresholds in real time, researchers and clinicians can instantly isolate clinically relevant events and balance data sensitivity with background noise.
Explore the Technology
KaryoSolver is fully integrated with ClinGen resources to ensure ACMG-compliant CNV interpretation, making it a market-ready tool tailored for modern clinical workflows. For more detailed technical specifications, application notes, and to access the official client user guide, please visit the dedicated product page on the 4bases KaryoSolver Hub.
Last update
30.06.2026