Research Areas Single-Cell Omics

Single-Cell Transcriptomics and Epigenomics

A key pillar of our group is the advancement of single-cell, spatial, and integrative multi-omics approaches to investigate the molecular mechanisms underlying human disease. By leveraging high-resolution molecular profiling technologies, we explore cellular heterogeneity and tissue organization at unprecedented resolution, enabling the characterization of distinct cellular states, regulatory programs, functional trajectories, and their spatial context across complex biological systems. Our research integrates multiple layers of information, including transcriptomic, epigenomic, genomic, proteomic, and spatial data, to move beyond descriptive analyses and generate mechanistic insights into disease biology. This integrative framework enables the reconstruction of cellular, regulatory, and tissue-level landscapes, supporting the interpretation of how molecular alterations influence cellular behavior, intercellular interactions, and tissue architecture in different pathological contexts. These activities are applied across several biomedical areas, with particular emphasis on immunology, oncology, and translational medicine.